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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Skin irritation Test (24h exposure on abraded skin) - no further details reported
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-ethynylphenol
Cas Number:
2200-91-1
Molecular formula:
C8H6O
IUPAC Name:
4-ethynylphenol
Test material form:
liquid
Details on test material:
- Test Material name (as cited in the study): C-979
- Chemical name: 4-ethynylphenol
- Formula: C8H6O
- Description: dark brownish-black liquid
- Date Received: 04.02.1986
- Density: 1.05 g/mL

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no further details stated in the report

Test system

Type of coverage:
not specified
Preparation of test site:
abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
24 h
Observation period:
min. 72 h, no further details stated in the report
Number of animals:
4
Details on study design:
Test material was removed with acetone after 24h.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
72 h
Score:
1
Reversibility:
not specified
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
72 h
Score:
1
Reversibility:
not specified
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
72 h
Score:
2
Reversibility:
not specified
Irritation parameter:
erythema score
Basis:
animal #4
Time point:
72 h
Score:
2
Reversibility:
not specified
Irritation parameter:
edema score
Basis:
animal #1
Time point:
72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Time point:
72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Time point:
72 h
Score:
1
Reversibility:
not specified
Irritation parameter:
edema score
Basis:
animal #4
Time point:
72 h
Score:
0
Irritant / corrosive response data:
C-979 produced slight dermal irritation. Two of the four animals exhibited very slight (barely perceptable) erythema witnout edema. Two animals exhibited slight erythema with or without edema.
Other effects:
Not reported.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Under the conditions of this study, the 4-ethynylphenol is considered to be slightly irritating to rabbit skin.