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EC number: 204-598-6
CAS number: 123-07-9
Skin irritation read-across: In a dermal irritation study with rabbits the skin irritation potential of 4-ethynylphenol was investigated. 4-Ethynylphenol caused only a slight skin irritation with very slight to slight erythema. Since a read across from 4-ethynylphenol to 4-ethylphenol is appropriate due to expected comparable toxicological properties, similar skin irritation properties can be expected for 4-ethylphenol. According to classification criteria outlined in Regulation (EC) No 1272/2008, 4-ethylphenol is therefore not to be classified with respect to acute dermal toxicity.
Eye irritation read-across: In an eye irritation study with rabbits the eye irritation potential of 4-ethynylphenol was investigated. 24 h after administration of 0.1 ml all animal showed a moderate to serve conjunctival irritation, iritis and corneal opacity. The severe eye irritation was still present at the end of the observation period seven days after exposure. Therefore, 4-Ethynylphenol is supposed to be highly irritating to eyes. Since a read across from 4-ethynylphenol to 4-ethylphenol is appropriate due to expected comparable toxicological properties, similar eye irritation properties can be expected for 4-ethylphenol.
Based on information available for a read-across chemical, 4-ethylphenol is not to be classified according to Regulation (EC) No 1272/2008 in terms of skin irritation.
Based on information available for a read-across chemical, 4-ethylphenol is considered to meet the classification criteria for Eye damage 1, “Causes serious eye damage” (H318).
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