Registration Dossier
Registration Dossier
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EC number: 204-598-6 | CAS number: 123-07-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb. 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute Dermal Toxicity Test (1986) - no further details reported
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-ethynylphenol
- Cas Number:
- 2200-91-1
- Molecular formula:
- C8H6O
- IUPAC Name:
- 4-ethynylphenol
- Test material form:
- liquid
- Details on test material:
- - Test Material name (as cited in the study): C-979
- Chemical name: 4-ethynylphenol
- Formula: C8H6O
- Description: dark brownish-black liquid
- Date Received: 04.02.1986
- Density: 1.05 g/mL
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no further details stated in the report
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test material was removed with acetone after 24 h.
- Duration of exposure:
- 24 h
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- no further details stated in the report
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality
- Clinical signs:
- other: no gross signs of toxicity
- Gross pathology:
- not reported
- Other findings:
- not reported
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the LD50 of 4-ethynylphenol is considered to be > 5000 mg/kg bw.
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