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EC number: 204-598-6
CAS number: 123-07-9
Acute toxicity, oral route:
In an acute oral toxicity study with rats equivalent to OECD Technical Guideline 401 no mortality occurred after administration of 2000 mg/kg bw of 4-ethylphenol.
Furthermore, no abnormalities were recorded at necropsy 14 day after administration. 10 min after administration of 2000 mg/kg clinical signs like rapid breathing and a staggering gait were observed. These symptoms disappeared two hours after administration and no clinical signs were found later until the end of the study except of significantly lower male body-weights. The median lethal dose of the tested material after single oral administration to rats of both sexes, observed over a period of 14 days, is: LD50 (rat): > 2000 mg/kg body weight. According to classification criteria outlined in Regulation (EC) No 1272/2008, 4-ethylphenol is not to be classified with respect to acute oral toxicity.
Acute toxicity, dermal route:
Read-Across: No systemic toxicity was observed after single dermal application of 5000 mg/kg bw of 4-ethynylphenol on rabbits and no critical effects were observed. Since a read across from 4-ethynylphenol to 4-ethylphenol is appropriate due to expected comparable toxicological properties, the median lethal dose (LD50) of 4-ethylphenol after single dermal administration is considered >5000 mg/kg body weight. According to classification criteria outlined in Regulation (EC) No 1272/2008, 4-ethylphenol is not to be classified with respect to acute dermal toxicity.
As a part of an investigation into the
safety of chemical substances in the OECD’s Existing Chemicals Database,
a dose of 0 mg/kg (control group) and 2000 mg/kg of 4-ethylphenol was
administered orally to groups of 5 species of each male and female
Crj:CD (SD) IGS rats per group in a single dose to examine its acute
As a result, a staggering gait starting 10
minutes after administration, successively a prone or lateral position
and rapid breathing of the male and female animals were observed as
poisoning symptoms in the 2000 mg/kg administered group. It was
considered that the expression of these symptoms was caused by direct
action of the test material but since all symptoms receded two hours
after administration, they seem to be a temporary change. Afterwards
until the ending day of the observation period 14 days after
administration no abnormality was observed.
The bodyweight of the males and females was
significantly low one day and three days after administration compared
to the control group. The value for the males was significantly low
during the observation period from 5 days after administration onwards,
and also the body weight increment and the body weight growth rate was
On the other hand, no significant difference
was found for the females from 5 days up to 14 days after administration
but a difference in the recovery condition of males and females was
observed. However, in the autopsy 14 days after administration no
abnormalities caused by the administration of the test material were
found in both males and females.
Accordingly, if 2000 mg/kg of 4-ethylphenol
is administered orally in a single dose temporarily a staggering gait, a
prone or lateral position and rapid breathing occurred as sudden
poisoning symptoms but did not result in the death of the animals,
therefore the LD50 value was estimated to be more than 2000 mg/kg for
both males and females.
4-Ethylphenol was administered orally in a
dose of 0 mg/kg (control group) and 2,000 mg/kg to groups of 5 of each
male and female Crj:CD (SD) IGS rats per 1 group in a single dose to
examine its acute toxicity.
The following results were obtained.
1. As no male or female rat died, it was
estimated that the LD50-value is above 2,000 mg/kg for both males and
2. In the general appearance, 10 minutes
after administration a staggering gait and successively a prone or
lateral position and rapid breathing was observed in male and female
animals of the 2,000 mg/kg administered group. These symptoms receded
until two hours after the end of administration and no abnormalities
were found later until the end of the observation period of 14 days.
3. The average body weight of the males of
the 2,000 mg/kg administered group had a significantly low value
compared to the control group during the observation period from 1 day
to 14 days after administration and the weight increment and the weight
growth rate were significantly low, too. On the other hand, the values
of the females were significantly lower compared to the control group 1
day and 3 days after administration but no significant difference was
observed from 5 days up to 14 days after administration.
4. No abnormalities caused by the
administered test compound were found by the autopsy 14 days after
administration in both male and female rats.
Based on information available for 4-ethylphenol and for a read-across chemical, 4-ethylphenol is not to be classified according to Regulation (EC) No 1272/2008 for acute oral and dermal toxicity.
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