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EC number: 941-167-8
CAS number: 1584709-99-8
The vehicle control plates gave counts of
revertant colonies within the normal range. All of the positive control
chemicals used in the test induced marked increases in the frequency of
revertant colonies, both with or without metabolic activation. Thus, the
sensitivity of the assay and the efficacy of the S9-mix were validated.
The maximum dose level of the test item in
the first experiment was selected as the maximum recommended dose level
of 5000 μg/plate. The test item induced a visible reduction in the
growth of the bacterial background lawns of all of the tester strains in
the absence of S9-mix, initially from 150 μg/plate (TA1537), 500
μg/plate (TA1535, TA98 and WP2uvrA) and 1500 μg/plate (TA100). In the
presence of S9-mix, weakened lawns were noted from 1500 μg/plate
(TA1535, TA98, WP2uvrAand TA1537) and at 5000 μg/plate (TA100).
Consequently, depending on bacterial strain type, the same maximum dose
level and the toxic limit was employed in the second mutation test. Main
test results once again showed a visible reduction in the growth of the
bacterial background lawns of all of the tester strains, initially from
150 μg/plate (TA1537) and 500 μg/plate (TA100, TA1535, TA98 and WP2uvrA)
in the absence of S9-mix. In the presence of S9-mix, weakened lawns were
noted from 500 μg/plate (TA1535) and 1500 μg/plate (TA100, TA98, WP2uvrA
and TA1537). No test item precipitate was observed on the plates at any
of the doses tested in either the presence or absence of S9-mix.
There were no toxicologically significant
increases in the frequency of revertant colonies recorded for any of the
bacterial strains, with any dose of the test item, either with or
without metabolic activation in both experiments. A small, statistically
significant increase in TA1537 revertant colony frequency was observed
in the absence of S9-mix at 150 μg/plate in the range-finding test. This
increase was considered to be of no biological relevance because there
was no evidence of a dose-response relationship or reproducibility.
Furthermore, the response was accompanied by weakened bacterial
background lawns and was, therefore considered spurious.
Under the test condition, test substance is
not mutagenic with and without metabolic activation in S. typhimurium (strains
TA1535, TA1537, TA98 and TA100) and E.coli WP2 uvrA- .
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