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EC number: 941-167-8
CAS number: 1584709-99-8
7.3.2/1: Eye irritation response data for each animal at each
Score at time point
0 / 0 / 0
1 / 0 / 0
2 / 2 / 2
1 / 1 / 1
2 / 1 / 1
0 / - / -
Average 24, 48 and 72 h
0.0 / 0.0 / 0.0
1.7 / 0.7 / 0.7
1.0 / 0.3 / 0.3
0.3 / 0.0 / 0.0
Average time (unit) for reversion
an eye irritation study performed according to the OECD Guideline No.
405, and in compliance with GLP, 0.1 mL of undiluted test item was
instilled into the right eye of 3 New Zealand White rabbits (1 female
and 2 males). The upper and lower eyelids were held together for about
one second immediately after application, to prevent loss of the test
material, and then released. The left eye remained untreated and served
as control. The eyes were examined and the changes were observed at 1,
24, 48, 72 h and 7 days after treatment and graded according to the
initial pain reaction was noted in any animal following instillation of
the test item. No corneal effects were noted during the study. Iridial
inflammation was noted in one treated eye one hour after treatment.
Moderate conjunctival irritation was noted in all treated eyes 1 h after
treatment. Moderate conjunctival irritation was noted in one treated eye
with minimal conjunctival irritation noted in two treated eyes at the 24
h observation. Minimal conjunctival irritation was noted in all treated
eyes at the 48 h observation and persisted in one treated eye at the 72
h observation. Two treated eyes appeared normal at the 72 h observation
and one treated eye appeared normal at the 7 day observation.
individual scores at 24, 48 and 72 h after exposure for the 3 animals
were 0.0 / 0.0 / 0.0 for cornea score; 0.0 / 0.0 / 0.0 for iris score;
1.7 / 0.7 / 0.7 for conjunctivae score and 1.0 / 0.3 / 0.3 for chemosis
the test conditions, the test substance is not classified as irritating
to eyes according to the criteria of the Regulation (EC) No. 1272/2008
(CLP) and to the GHS.
study is considered as acceptable and satisfies the requirement for eye
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