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EC number: 941-167-8
CAS number: 1584709-99-8
an acute dermal toxicity study (limit test) performed according to OECD
Guideline No. 402 and in compliance with GLP, a group of Wistar
(RccHan™:WIST) rats (5/sex) was given a single dermal application of the
undiluted test substance at 2000 mg/kg bw to intact skin of the back and
flank area at the dose volume of 2.12 mL/kg bw. Test sites were covered
with a semi-occlusive dressing for 24 h. Animals were observed for
mortality, clinical signs and bodyweights for 14 days and at the end of
the study the surviving animals were sacrificed for macroscopic
mortality or signs of systemic toxicity was observed. Very slight
erythema was noted at the test site of three females. Other signs of
dermal irritation noted were crust formation in one female and small
superficial scattered scabs and glossy skin in two females. There were
no signs of dermal irritation noted at the test sites of all males and
two females. Animals showed expected gains in bodyweight over the 14 day
study period. No abnormalities were noted at necropsy.
LD50 Combined > 2000 mg/kg bw
the test conditions, the test substance is not classified according to
the Regulation EC No. 1272/2008 (CLP) and to the GHS.
study is considered as acceptable and satisfies the requirement for
acute dermal toxicity endpoint.
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