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EC number: 483-360-5
CAS number: 114435-02-8
Table 1: Dpm, Dpm/Node and Stimulation
Concentration (% w/w) in dimethyl formamide
Stimulation Index (SI)b
= Dpm/node obtained by dividing the Dpm value by 8 (total number of
= Stimulation Index of 3.0 or greater indicates a positive result
= Not applicable
Mortality: There were no deaths.
Clinical observations: No signs of systemic
toxicity were noted in the test or control animals during the test.
Bodyweight: Bodyweight changes of the test
animals between Day 1 and Day 6 were comparable to those observed in the
corresponding control group animals over the same period.
A study was performed to assess the skin
sensitisation potential of Monofluoroethylene carbonate in the CBA/Ca
strain mouse following topical application to the dorsal surface of the
ear. The method was designed to meet the requirements of the following:
- OECD Guideline for the Testing of
Chemicals No. 429 "Skin Sensitisation: Local Lymph Node Assay" (adopted
24 April 2002)
- Method B42 Skin Sensitisation (Local Lymph
Node Assay) of Commission Directive 2004/73/EC
Following a preliminary screening test,
three groups, each of four animals, were treated with 50 μL (25 μL per
ear) of the test material as a solution in dimethyl formamide at
concentrations of 10%, 25% or 50% w/w. A further group of four animals
was treated with dimethyl formamide alone.
The Stimulation Index (SI) expressed as the
mean radioactive incorporation for each treatment group divided by the
mean radioactive incorporation of the vehicle control group are as
Concentration (% w/w) in
Stimulation index (SI)
Monofluoroethylene carbonate was considered
to be a sensitiser under the conditions of the test.
An inverse dose response relationship was
noted in the Stimulation Index results. The reason for this is unknown
but could be due to decreased bioactivity of the test material with
increasing concentrations in dimethyl formamide, or due to
immunosuppression at higher concentrations of test material.
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