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EC number: 483-360-5
CAS number: 114435-02-8
Table 1 : Mean measured concentration of F1EC in test solutions based on fluoride
Nominal concentration of F1EC
Measured concentration of F1EC based on fluoride (*)
Mean measured concentration of F1EC (***)
(*) The measured concentration fluoride originates from F1EC, however at
the time of measurement F1EC itself was hydrolyzed.
(**) In the algal medium a small amount of fluoride was detected. As the
amount was > 10% of the lowest test concentration, a correction for the
background measured at 0 mg/L was used.
(***) Between brackets the percentage of nominal concentration is given.
Table 2 : Mean measured algal cell densities during the test period, biomass integral inhibition and mean growth rate inhibition
mean cell density x 10E4 (*)
Biomass integral inhibition on day 3
Growth rate inhibition day 0 -3
(*) On day 0 the cell density of the preculture was determined. Based on
this result 0.353 mL of the preculture was added to Erlenmeyer flasks
resulting in an initial concentration of 1.0 x 10E4 cells/mL.
The toxicity of F1EC (MONOFLUOROETHYLENE CARBONATE) to algae (Selenastrum
capricornutum) was tested according to the OECD GLP Principles to
the OECD Guideline 201(OECD,1984).
Based on the results of a preliminary study, the study was conducted at
nominal concentrations of 1.0, 2.2, 5.0, 11 and 25 mg/L. The fluoride
content of the test solutions was measured with cuvette test LCK 323.
Based on these results, the difference between the nominal and the mean
measured concentrations was < 20% and for this reason the endpoints of
the test were based on nominal concentrations.
The cell density increased 121 - 155 times in the controls, which meets
the validity criterion of a minimal of 16 times increase. The pH of
controls was 7.8 on day 0 and 8.5 on day 3 which is in accordance with
the validity criterion of a maximum increase of 1.5 pH unit.
The cell density measurements were used to calculate the biomass
integral and growth rate for each replicate. Using linear interpolation
the 72h-EC50 for biomass integral and growth rate were 6.3 and 32 mg/L,
respectively. The No Observed Effect Concentration (NOEC), based on
biomass integral and growth rate at test termination, was determined to
be 1 mg/L with Williams' Test (Williams, 1972). Based on biological
significance/relevance (i.e. inhibition < 10%) the NOEC was 2.2 mg/L.
The 72h NOEC (biological significance) and the 72h ErC50 of the
substance to algae were determined to be 2.2 and 32 mg/L based on the
growth rate respectively.
There is no data available for marine algae species.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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