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EC number: 412-570-1
CAS number: 119462-56-5
Maximum concentration not causing irritating effects in preliminary test: 10 %.
Signs of irritation during induction:
Intradermal induction gave rise to barely-perceptible to
moderate erythema, pallor and discolouration.
Topical induction gave rise to barely perceptible or slight
erythema, but eschar formation and exfoliation.
Evidence of sensitisation of each challenge concentration:
A significant response was observed in 19 test and one control animal.
A skin sensitization test according to OECD guideline 406 (Guinea Pig
Maximization Test, GPMT) was conducted on guinea pigs with test
substance formulations in propylene glycol of 0.1% for intradermal
induction and 0.3 and 3% for topical induction. In the challenge phase
of the experiment test concentrations of 3 and 0.3% (in propylene
glycol) were applied. A significant response (slight erythema or a more
marked reaction) was observed in 19 test and one control animal after
challenge with 3%. Six test animals and no control animals responded to
0.3% of the test item. Thus, under the conditions of this assay the test
item has to be regarded as skin sensitizer in Guinea pigs.
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