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EC number: 412-570-1
CAS number: 119462-56-5
In a GPMT test Perkalink was tested positive in 19/20 animals; only 1/20
controls showed a positive reaction.
Maximum concentration not causing irritating effects in preliminary test: 10 %.
Signs of irritation during induction:
Intradermal induction gave rise to barely-perceptible to
moderate erythema, pallor and discolouration.
Topical induction gave rise to barely perceptible or slight
erythema, but eschar formation and exfoliation.
Evidence of sensitisation of each challenge concentration:
A significant response was observed in 19 test and one control animal.
A skin sensitization test according to OECD guideline 406 (Guinea Pig
Maximization Test, GPMT) was conducted on guinea pigs with test
substance formulations in propylene glycol of 0.1% for intradermal
induction and 0.3 and 3% for topical induction. In the challenge phase
of the experiment test concentrations of 3 and 0.3% (in propylene
glycol) were applied. A significant response (slight erythema or a more
marked reaction) was observed in 19 test and one control animal after
challenge with 3%. Six test animals and no control animals responded to
0.3% of the test item. Thus, under the conditions of this assay the test
item has to be regarded as skin sensitizer in Guinea pigs.
Based on complaints in workers it was concluded that the test substance
should be regarded as skin sensitizer for humans.
The test item was shown to be a skin sensitizer in Guinea pigs and
humans. The guideline-conform Guinea Pig Maximization Assay showed 95%
responding animals after treatment with 0.1% test item for intradermal
induction. According to CLP classification criteria (Regulation (EC) No
1272/2008) a self-classification with Skin Sens. 1A is warranted. The
test substance is classified according to Regulation 1272/2008, Annex VI
with Skin Sens. 1.
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