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EC number: 412-570-1
CAS number: 119462-56-5
Based on the acute dermal toxicity study (LD50 > 2000 mg/kg bw), a 5-day
dermal range-finding study was carried out with 1000 and 300 mg/kg
bw/day. This resulted in severe skin damage with local or generalised
erythema, necrosis and scab formation. Renewed range finding with 100
and 30 mg/kg bw/day gave identical results, viz. 30 mg/kg bw induced
severe local effects appearing on days 3, 4 and 5.
In a 5 day dermal range-finding study corrosive effects were observed at
the 1000 and 300 mg/kg dose level. Therefore, a new pilot study was
conducted using dose levels of 30 and 100 mg/kg body weight/day at the
maximized dose volume of 7.5 ml/kg body weight. Again severe local
effects were noted. As in the first pilot study no skin effects were
seen on the first 2-3 days of treatment but appeared on day 3 and later.
Thus, these effects may likely be related to the sensitisizing capacity
of PERKALINK 900 (as indicated in a Guinea Pig Maximisation Test).
Treatment of further animals at lower dose levels was was deemed not to
provide useful information with regard to systemic toxicity.
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