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EC number: 412-570-1
CAS number: 119462-56-5
The developmental toxicity of PERKALINK 900 was studied in a
GLP-compliant OECD 414 guideline study in which female rats received 0,
800, 1600 and 3200 mg/kg diet in an oral feeding study. Animals were
exposed from GD 0-21. The NOAEL for maternal toxicity was 1600 mg/kg
diet (105 mg/kg bw/day) based on statistically significant effects on
body weight, body weight change, food consumption, carcass weight and
net weight change.
Since no effects were observed on fertility, reproductive performance,
reproductive organ weights, litter data, fetal external, visceral, and
skeletal examinations, the NOAEL for reproducive and developmental
toxicity is at least 3200 mg/kg diet (196 mg/kg bw/day), the highest
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