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EC number: 412-570-1
CAS number: 119462-56-5
Experimental toxicokinetic studies are not available. The log Kow does not point to a bioaccumulation potential. Oral and dermal absorption was shown in toxicological studies.
PERKALINK 900 is used as anti-reversion agent in the manufacture of
natural rubber articles such as the treads of tyres, conveyor belts and
solid tyres. Anti-reversion agents help repair the sulfur cross-links
that break as a result of exposure of the rubber articles to high
temperatures resulting from both friction and the vulcanising process.
After processing the substance is chemically bound to the rubber matrix.
PERKALINK 900 is considered as mono constituent.
PERKALINK 900 is handled as dust-free pastilles with a very low vapour
pressure under normal ambient conditions (0.00005 Pa at 20°C, Cowlyn,
1993). Inhalation exposure to the vapour is therefore not to be expected.
Physicochemical properties of PERKALINK 900:
Molecular weight: 324 g/mole
Water solubility: 40.8 mg/L at 20°C
Partition coefficient: log Kow = 2.22
The following remarks on toxicokinetics are based on the
physico-chemical properties of PERKALINK 900 and on toxicological data.
Experimental studies on toxicokinetics were not performed.
The physicochemical characteristics of PERKALINK 900 (log Kow of 2.22)
and the molecular mass are in the range suggestive of absorption from
the gastrointestinal tract subsequent to oral ingestion. This is
confirmed by data obtained in a 2-generation feeding study on rats which
showed signs of systemic toxicity.
Dermal absorption of PERKALINK 900 is favoured by its log Kow. The water
solubility is also in the range that allows dermal penetration.
PERKALINK 900 is no skin irritant after single dermal exposure but it is
a strong skin sensitizer when repeatedly applied to the skin. The latter
implies that some dermal penetration did occur.
PERKALINK 900 is a strong irritant to mucosal membranes.
Based on the results of several mutagenicity tests it can be assumed
that no DNA-reactive metabolites will be generated in mammals in the
course of hepatic biotransformation of PERKALINK 900.
The log Kow of 2.22 does not indicate a relevant bioaccumulation
potential of PERKALINK 900.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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