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EC number: 939-707-2
CAS number: -
Irritant/corrosive response data for each animal at each observation
time up to removal of each animal from the test
Score at time point / Reversibility
Max. score: 4
0 / 0 / 0
0 / 0 / 1
1 / 0 / 0
0 / 1 / 2
1 / 0 / 2
0 / 0 / 2
1 / 0 / 1
0 / 0 / 1a
0 / 0 /0f
Average 24h, 72h
0.0 /0.33/ 1.7
0.33/ 0.0 /1.7
0.0 /0.33/ 1.0
0.66 / 0.0 / 1.0
Average time (unit) for reversion
*) Reversibility: c. =
not completely reversible; n. = not reversible
a = skin appeared dry
f = flaking skin
a primary dermal irritation study (1994), New Zealand Albino rabbits (3
animals) were dermally exposed to 0.5
g of undiluted
test article. Intact and abraded test sites were covered with an
occlusive dressing for 4 hours. Skin sites were then scored for erythema
and oedema 3 min, 1 hour, 4, 24, 48, 72 hours and day 7 after patch
removal. Irritation was scored by the method of Draize.
Erythema, absent at
3 minutes post
dose, was absent to slight at one and four hours. At 24 and 48 hours
after patch removal, erythema was absent to well defined. At 72 hours
erythema was absent to slight and absent on day 7. Edema, absent at
3 minutes post
dose, was absent to slight at one and four hours. At 24 hours after
patch removal, edema was absent to well defined. Edema was absent to
slight at 48 hours and absent at 72 hours and on day 7.
Mean scores over 24,
48 and 72 hours for each animal were 0.0, 0.33
and 1.7 for
erythema and 0.0, 0.33
and 1.0 for
edema. Similar effects were observed with abraded skin. The modified
primary irritation index is 1.17.
Under the experimental
conditions of this study, the test item was slightly irritant when
applied topically to rabbits. Based
on these results, the test item reaction product of naphthalene,
propan-2-ol, sulfonated and neutralized by caustic soda is not
classified as irritating to the skin according to Annex VI of the
Directive 67/548/CEE and to EU Regulation 1272/2008 (CLP).
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