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EC number: 700-195-9
CAS number: 223398-24-1
Two groups, one of three female and one of
three male HanRcc: WIST(SPF) rats, were treated with GRO 266 by oral
gavage administration at a dosage of 2000 mg/kg bw. The test item was
diluted in vehicle (purified water) at a concentration of 0.2 g/ml and
administered at avolume of 10 ml/kg.
The animals were examined daily during the
acclimatization period and mortality, viability and clinical signs were
recorded. All animals were examined for clinical signs within the first
30 minutes and approximately 1,2,3 and 5 hours after treatment on day 1
and ance daily during test days 2 -15. Mortality/viability was recorded
at approximately 30 minutes, 1,2,3 and 5 hours after administration on
test day 1 (with the clinical signs) and twice daily during days 2 -15.
Body weights were on day 1 (prior to administration) and on days 8 and
15. All animals were necropsied and examined macroscopally.
All animals survived until the end of the
One hour after treatment all female animals
showed slightly ruffled fur which persisted up to the 5-hour reading. In
the male animals slightly ruffled fur was observed 5 hour after
treatment. There were no further clinical signs noted until test day 15,
the end of observation time.
The body weight of the animals was within
the range commonly recorded for this strain and age.
No macroscopic findings were recorded at
The median lethal dose of GRO 266 after
single oral administration to rats of both sexes, observed over a period
of 14 days is:
LD50(rat): greather than 2000 mg/kg body
This result corresponds to Category 5 or
Unclassified based on the GHS classification criteria and an LD50 cut
off of 5000 mg/kg body weight according to the OECD 423 Test Procedure.
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