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EC number: 700-195-9
CAS number: 223398-24-1
This study was performed to investigate the potential
of GRO 266 to induce gene mutations according to the plate incorporation test
(experiment I) and the pre-incubation test (experiment II) using the Salmonella
typhimurium strains TA 1535, TA 1537, TA 98, TA 100, TA 102.
The assay was performed in two independent experiments
both with and without liver microsomal activation. Each concentration, including
the controls, was tested in triplicate. The test item was tested at the following
Pre-Experiment/Experiment I: 3, 10, 33, 100, 333,
1000, 2500 and 5000 µg/plate
Experiment II: 33,
100, 333, 1000, 2500 and 5000 µg/plate
The plates incubated with the test item showed
normal backround growth up to 5000 µg/plate with and without S9 mix in
all strains used.
No toxic effects, evident as a reduction in the
number of revertants (below the indication factor of 0.5), occured in the
test groups with and without metabolic activation.
No substantial increase in relevant colony numbers
of any of the five tester strains was observed following treatment with GRO
266 at any dose level, neither in the presence nor absence of metabolic activation
(S9 mix). There was also no tendency of higher mutation rates with increasing
concentrations in the range below the generally acknowledged border of biological
Appropriate reference mutagens were used as positive
controls and showed a distinct increase of induced revertant colonies.
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