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EC number: 203-784-4
CAS number: 110-62-3
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In an acute eye irritation/corrosion
test, 2 rabbits were exposed to 0.05 mL valeraldehyde each. Irritation
reactions of cornea and conjunctivae developed within 1 hour after
application and persisted up to a maximum of 8 days. At the end of the
observation period (8 days) all irritation effects had subsided.
For rabbit 1, the mean (24 and 48 h,
no reading at 72 h) cornea and conjunctivae scores were 0.5 and 1.5
respectively. For rabbit 2, the mean cornea and conjunctivae scores were
1.5 and 2 thus exceeded or reaching the EU criteria for classification
(reversible effect on the eye - Category 2) (BASF 1977). Considering the
dose applied and the time course of the development of irritating
effects, valeraldehyde requires classification as irritating to eyes
For recent primary eye irritation
tests in vivo, test guidelines require the application of 0.1 mL test
substance. Considering the data available and the time course of the eye
irritating effects, it is estimated that with the higher dose, scores
will be elevated but still remain below the criteria for irreversible
effects and the reversibility of effects within 21 days will be
maintained. Based on the data available, valeraldehyde will be
classified as irritating to eyes (Category 2).
This study bears some deviations from
actual test guidelines. Nevertheless, the data are assessed to be
sufficiently valid to evaluate the eye irritation potential of
valeraldehyde. Using available results conforms to the tiered testing
and evaluation strategy for eye irritation/corrosion and further testing
can be avoided.
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