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EC number: 203-784-4
CAS number: 110-62-3
The acute dermal LD50 was reported as
6 mL/kg bw. Using a density of 0.8095 g/mL (Auer Technikum Edition 12,
Auergesellschaft GmbH, Berlin, 198
The acute dermal toxicity of
valeraldehyde was determined in groups of 4 male albino New Zealand
rabbits receiving graduate single doses of test substance per group.
Number and quantity of individual doses are not specified. The exposure
time was 24 hours followed by an observation period of 14 days.
Individual data on mortality, weight development, clinical signs and
gross necropsy findings are not reported. From mortality data, the LD50
and a range of ± 1.96 SD was calculated according to the method of
The acute dermal LD50 for valeraldehyde
was determined to be 4857 mg/kg bw in rabbits (Smyth, 1969).
Overall, the study was conducted
similar to OECD test guideline 402 with some restrictions (only 4
animals per group, occlusive wrapping, limited reporting). The
deviations from the test guideline are considered not to invalidate the
result. It is rather estimated that the value determined is close-by a
result from a test in compliance with the test guideline and will be
located within its range of uncertainty.
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