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Diss Factsheets
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EC number: 200-554-5 | CAS number: 63-05-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling point/boiling range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Key result
- Decomposition:
- yes
- Decomp. temp.:
- 200 °C
- Remarks on result:
- other: decomposition before boiling
- Conclusions:
- Reaction and/or decomposition of the test substance was observed starting at 200°C (473K).
- Executive summary:
The boiling point of the substance was investigated using the European Community Guideline A.2 which corresponds in main parts to the OECD guideline 103.
Reaction and/or decomposition of the test substance was observed starting at 200°C (473K). Boiling of the test substance was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test substance has no boiling temperature.
Reference
Preliminary test:
From 300°C upwards the weight of the sample decreased significantly. At 402°C the sample weight had decreased by 25%.
After the experiment, a brown molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test substance.
Main study:
An endothermic peak between 150°C and 200°C was observed. The effect was due to melting of the test substance. A broad exothermic effect was observed starting at 200°C. This effect was due to reaction and/or decomposition of the test substance. After the experiment, a yellow molten residue remained in the sample container.
Validity criteria for the measurement of the boiling point:
Target condition according to guideline OECD 103: | Actual condition according to the study: | Validity criteria met: |
The heating rate should not exceed 10 K/min. | Heating rate was 5 K/min. | Yes |
The mean of at least two measurements which are in the range of the estimated accuracy (accuracy for this method according to the guideline is +/- 0.5 K up to 600 K) is reported as the boiling temperature. | Two determination was done with no determination of a boiling point. | Yes |
The measured boiling temperatures and their mean shall be stated and the pressure(s) at which the measurements were made shall be reported in kPa. The pressure should preferably be close to normal atmospheric pressure. | The atmospheric pressure is stated. | Yes |
Description of key information
Reaction and/or decomposition of Androst-4-ene-3,17-dione was observed starting at 200 °C (473 K).
Key value for chemical safety assessment
- Temperature of decomposition (state purity):
- 200 °C
Additional information
Boiling of the test substance was not observed below the temperature at which reaction and/or decomposition started.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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