Registration Dossier
Registration Dossier
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EC number: 200-554-5 | CAS number: 63-05-8
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 Apr 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- yes
- Dissociating properties:
- no
- Conclusions:
- Androst-4-ene-3,17-dione can be considered as a neutral molecule in the pH range 2 -10, which is of relevance for biological systems.
- Executive summary:
The estimation of the acid-base properties are based on the chemical structure und measurements of UV-spectra. The UV/VIS spectra of the test item were measured in buffers (pH 2, 7 and 12). No spectral change was observed in the pH-range 2-12 and though Androst-4-ene-3,17-dione can be considered as a neutral molecule in environmentally relevant pH-ranges.
Reference
The UV/VIS spectra of the substance were measured in buffers (pH= 2, 7 and 12). No spectral change was observed. The substance can be considered as a neutral molecule in these pH ranges.
Description of key information
Androst-4-ene-3,17-dione can be considered as a neutral molecule in the pH range 2 -10.
Key value for chemical safety assessment
Additional information
No spectral change was observed in the pH-range 2-12 and though Androst-4-ene-3,17-dione can be considered as a neutral molecule in environmentally relevant pH-ranges.
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