Registration Dossier
Registration Dossier
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EC number: 200-554-5 | CAS number: 63-05-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 to 23 May 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 66 mg/L
- Temp.:
- 20 °C
- pH:
- 6.5
- Remarks on result:
- other: There is no change in the solid state form of the insoluble residue with respect to that one of the starting material.
- Conclusions:
- Androst-4-ene-3,17-dione can be considered as slightly soluble with a water solubility of 66 mg/L at 20 °C. The mean pH value of the saturated water solutions was determined to be 6.5.
- Executive summary:
The water solubility of the substance was determined to be 66 mg/L at 20°C and pH 6.5 according to the EU method A.6 with 95% confidence interval.
Reference
Validity criteria for the measurement of the water solubility:
| Target condition according to guideline OECD 105: | Actual condition according to the study: | Validity criteria met: |
| The test is preferably run at 20 ± 0.5 °C. | The test was performed at 20 °C. | Yes |
| A substance-specific analytical method is preferred for these determinations, since small amounts of soluble impurities can cause large errors in the measured solubility. Examples of such methods are: gas or liquid chromatography, titration methods, photometric methods, voltametric methods. | HPLC was used for analytical measurements. | Yes |
| The pH of each sample should be recorded. | The pH of each sample is reported. | Yes |
Description of key information
Androst-4-ene-3,17-dione can be considered as slightly soluble with a water solubility of 66 mg/L at 20 °C. The mean pH value of the saturated water solutions was determined to be 6.5.
Key value for chemical safety assessment
- Water solubility:
- 66 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
