Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-554-5 | CAS number: 63-05-8
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- not specified
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- other: Differential thermal analysis in combination with thermogravimetry (DTA/TG)
- Melting / freezing pt.:
- 172 °C
- Remarks on result:
- other: No pressure is reported
- Conclusions:
- Androst-4-ene-3,17-dione melts at 172 °C (445± 1K) and no pressure was reported.
- Executive summary:
The melting point of the substance of 172°C was tested according to OECD Guideline 102 by DTA/TG measurements with a heating rate of 5 K/min on a Setaram TG DSC 111 in open aluminum crucibles under nitrogen atmosphere and no pressure was reported.
Reference
Validity criteria for the measurement of the melting point:
| Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
| The heating rate should not exceed 2 K/min. | Heating rate 5 K/min. | No |
| The mean of at least two measurements which are in the range of the estimated accuracy is reported as the melting temperature. | Over twenty values were determined in several polymorphs. | Yes |
| If the substance decomposes or sublimes before the melting temperature is reached, the temperature at which the effect is observed shall be reported. | The test substance does not decompose before melting point was reached. | Yes |
Description of key information
Androst-4-ene-3,17-dione melts at 172 °C (445 ± 1 K) and no pressure was reported.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 172 °C
Additional information
Androst-4-ene-3,17-dione is a solid under ambient conditions. It is found to exist in at least two anhydrate forms, called polymorph I and II. The investigated production and laboratory crystallization products consist of polymorph I.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
