Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The potential of hexaoxatricosane to cause skin sensitization was tested in GLP compliant Buehler Test according to OECD test guidelines 406 (Longobardi, 2004). During the induction phase twenty female guinea pigs were exposed epicutaneously to the undiluted test substance. Challenge was performed with the 75% test substance in sterile water, and no skin reaction was observed 24 or 48 hours following exposure.

A comparable result was obtained in a modified Buehler test in guinea pigs when undiluted hexaoxatricosane was applied during both, induction and challenge phase (Kuklinski, 1991).

No human information is available.


Migrated from Short description of key information:
Guinea pig, Buehler test: not skin sensitising (GLP, OECD 406, Longobardi 2004)

Respiratory sensitisation

Endpoint conclusion
Additional information:

No information available.


Migrated from Short description of key information:
no information available

Justification for classification or non-classification

Based on the available data on the skin sensitization of hexaoxatricosane no classification is warranted according to the criteria of both, 67/548/EEC and CLP regulation (EC) 1272/2008.

Furthermore, there is no information on potential of hexaoxatricosane respiratory sensitisation

, thus no classification is warranted according to the criteria of both, 67/548/EEC and CLP regulation (EC) 1272/2008.