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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment. No data on test concentration and particle size distribution.

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
according to Federal Hazardous Substances Labeling Act. Test animals were exposed whole body to hexaoxatricosan aerosol for 1 hour and observed for 14 days thereafter.
GLP compliance:
no
Test type:
other: Inhalation Hazard Test
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): TP-90B/6213
- Analytical purity: no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Not described
- Age at study initiation: Young adult
- Weight at study initiation: males 259-274 g; females 237-253 g


Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
other: no data
Details on inhalation exposure:
A group of ten young adult male and female rats, equally divided as to sex were exposed to an aerosol of TP-90B/6213 in an inhalation chamber for a period of 1 hour. The spray was directed away from the nasal and ocular areas and circulated throughout the chamber for the duration of the exposure. Maximum aerosolization of 200 mg/l was achieved prior to the test period. At the conclusion of the observation period, the survivors were sacrificed and gross necropsies were performed.
Duration of exposure:
1 h
Concentrations:
200 mg/l
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
The animals were observed for a fourteen day period following the exposure. At the conclusion of the observation period the animals were sacrificed and gross necropsies were performed.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
>= 200 mg/L air
Based on:
test mat.
Exp. duration:
1 h
Mortality:
No deaths observed.
Clinical signs:
other: During exposure the animals pawed at their nasal areas. After 35-40 minutes they became languid. Normality prevailed upon removal from chamber. Eating habits and behavior patterns remained normal throughout the observation period.
Gross pathology:
Since there were no abnormalities, histologic sections were not performed.

Any other information on results incl. tables

No mortality observed within 14 days after exposure to hexaoxatricosane mist for 1 hour.

Applicant's summary and conclusion