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Acute tests on all three trophic levels were performed to examine the aquatic toxicity. Algae turned out to be the most sensitive species revealing an EC50 (96h) of 53 mg/L. For daphnia the acute toxicity is EC50, 48 h = 87 mg/L. Thus, the substance is considered to be acutely harmful to aquatic organisms. Fish turned out to be less sensitive on bis(2-(2-butoxyethoxy)ethoxy)methane. The LC50 (96h) for rainbow trout was measured to be 491 mg/L.

No data on long-term toxicity on fish and Daphnia are available. The NOEC (96h) for algae was determined to be 11.4 mg/L. Hence the ratio of acute to chronic from the experimental results on algae is about 5. A comparable acute/chronic ratio (approx. 3) results from QSAR estimation (ECOSAR v1.00). Both chronic values (measured and estimated) are clearly above 1 mg/L.

For the daphnia a QSAR calculation gives an acute/chronic ratio of about 9. Based on the acute measured toxicity of 87 mg/L, a acute/chronic ratio of 9 would result in an NOEC of about 9.6 mg/L. Hence, the expected chronic toxicity on Daphnia is clearly above 1 mg/L.

The acute fish toxicity with a LC50 of about 500 mg/L and an acute NOEC of 43 mg/L is clearly the most insensitive species. With an acute value of 523 mg/L (LC50, 96h) and an chronic value of 62 mg/L (NOEC) the QSAR estimations (ECOSAR v1.00) confirms this results.

Combining the experimental results and the QSAR estimations chronic effects are not expected in low concentrations (< 1 mg/L). Based on this conclusion the hazard assessment needs not to classify the substance as dangerous for the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore, and for reasons of animal welfare, long-term toxicity studies in Daphnia and fish are not provided.