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EC number: 205-598-9
CAS number: 143-29-3
tests on all three trophic levels were performed to examine the aquatic
toxicity. Algae turned out to be the most sensitive species revealing an
EC50 (96h) of 53 mg/L. For daphnia the acute toxicity is EC50, 48 h = 87
mg/L. Thus, the substance is considered to be acutely harmful to aquatic
organisms. Fish turned out to be less sensitive on
bis(2-(2-butoxyethoxy)ethoxy)methane. The LC50 (96h) for rainbow trout
was measured to be 491 mg/L.
on long-term toxicity on fish and Daphnia are available. The NOEC (96h)
for algae was determined to be 11.4 mg/L. Hence the ratio of acute to
chronic from the experimental results on algae is about 5. A comparable
acute/chronic ratio (approx. 3) results from QSAR estimation (ECOSAR
v1.00). Both chronic values (measured and estimated) are clearly above 1
daphnia a QSAR calculation gives an acute/chronic ratio of about 9.
Based on the acute measured toxicity of 87 mg/L, a acute/chronic ratio
of 9 would result in an NOEC of about 9.6 mg/L. Hence, the expected
chronic toxicity on Daphnia is clearly above 1 mg/L.
acute fish toxicity with a LC50 of about 500 mg/L and an acute NOEC of
43 mg/L is clearly the most insensitive species. With an acute value of
523 mg/L (LC50, 96h) and an chronic value of 62 mg/L (NOEC) the QSAR
estimations (ECOSAR v1.00) confirms this results.
and the QSAR estimations chronic effects are not expected in low
concentrations (< 1 mg/L).
Based on this
conclusion the hazard assessment needs not to classify the substance as
dangerous for the environment, nor is it a PBT or vPvB substance, nor
are there any further indications that the substance may be hazardous to
the environment. Therefore, and for reasons of animal welfare, long-term
toxicity studies in Daphnia and fish are not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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