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EC number: 205-598-9
CAS number: 143-29-3
skin in vivo, rabbit, 4 h, semiocclusive: not irritant (GLP, OECD 404; Langobardi 2003) eyein vivo, rabbit: not irritant (GLP, OECD 405; Langobardi 2003)
Skin corrosion and skin irritation was
assessed in a GLP compliant study according to OECD test guideline 404
(Longobardi, 2003). Hexaoxatricosane was applied topically to three New
Zealand White rabbits for 4 hours under semiocclusive conditions. Skin
changes were scored at 1, 24, 48 and 72 hours after application
according to the Draize scoring system. No topical reactions was
observed 24, 48, and 72 hours after application of the test substance in
any of the tested rabbits. The individual mean score (24 to 72 hours) in
each of the three rabbits was 0.0 for both, edema and erythema.
In addition, topical exposure of 6 New
Zealand Albino rabbits to hexaoxatricosane for 4 hours under occlusive
conditions did not cause any skin reactions as well (Kuklinski
et al., 1991).
The potential of hexaoxatricosane to
cause serious eye damage and eye irriation was assessed in an GLP
compliant study according to OECD test guideline study 405 (Longobardi,
2003). When applied into the conjunctival sac of one eye of 3 New
Zealand White rabbits a slight irritant effect was observed 1 hour after
instillation. This effects was quickly reversible so that no eye
irritating effect was observed at the 24 , 48, and 72 hour readings time
points in all three tested animals.
No human information is available on
the corrosivity and irritation of hexaoxatricosane.
Based on the available data on the corrosivity and irritation of
hexaoxatricosane no classification is warranted according to the
criteria of both, 67/548/EEC and CLP regulation (EC) 1272/2008.
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