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EC number: 205-598-9
CAS number: 143-29-3
oralrat: LD50 > 2000 mg/kg bw (GLP, OECD 425; Langobardi 2003)dermalrat: L50 > 2000 mg/kg bw (GLP, OECD 402; Langobardi 2004)inhalationno reliable data availabe
There are reliable data available to
assess the acute toxicity of the substance after oral, dermal and
In a GLP compliant study performed
according to OECD test guideline 425 (Longobardi,
2003), 5 female Sprague-Dawley
rats received 2000 mg/kg bw of hexaoxatricosane by gavage and were
subsequently observed for 14 days. At the end of the observation period,
all survivors were sacrificed and submitted to gross-pathological
examination. One animal died at 2000 mg/kg bw within approximately one
hour of dosing, therefore the LD50 level was > 2000 mg/kg bw. The
clinical signs observed at 2000 mg/kg bw comprised convulsions,
lacrimation, salivation, lethargy, piloerection, reduced activity on day
1 and hunched posture on days 2 and 3. No abnormalities were observed in
any animal at the necropsy examination performed at the end of the
observation period or in the early decedent animal.
In a supporting study the acute oral
toxicity of hexaoxatricosane in Sherman Wistar rats was determined to be
approximately 3310 mg/kg (Shelanski, 1958)
There are two studies available
adressing the acute dermal toxicity of hexaoxatricosane
in two different species. In a
GLP compliant study according to OECD test guideline 402
male and female Spraque-Dawley rats (10/sex/dose) received a single
dermal dose of 2000 mg/kg bw over 24 hours (Longobardi,
2004). After removal of the test
substance the test animals were observed for 14 days. No mortality
occured. Apart from reduced body weight gain in the female group at the
end of the observation period no clinical signs of toxicity and no
pathological abnormalities were observed.
The findings in the key study are
supported by a second acute dermal toxicity study in rabbits (Green,
1977). Six male and six female rabbits were topically exposed to 2000
mg/kg bw of the test substance for 24 h. No mortalities and no signs of
toxicity were observed.
Limited information is available on the
acute inhalation toxictiy of hexaoxatricosane
For both, vapor and aerosol an inhalation hazard test with whole body
exposure for 1 hour was performed in rats
and mice. A very high aerosolic
concentration of 200 mg/l was reported. This value is not comprehensible
and therefore, the reference is considered as not reliable (Klimisch
No human information is available on
the acute toxicity (oral, dermal and inhalation) of hexaoxatricosane.
Based on the available data on the acute toxicity of hexaoxatricosane no
classification is warranted according to the criteria of both,
67/548/EEC and CLP regulation (EC) 1272/2008.
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