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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-879-8 | CAS number: 100-69-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 60 mg/kg bw/day
Effect on fertility: via dermal route
- Dose descriptor:
- NOAEL
- 60 mg/kg bw/day
Additional information
The NOAELs are based on observed changes in relative organ weights of testis and ovaries. There is no evidence of histopathology of the reproductive organs and no indication of adverse effects in fertility. The reproductive NOAEL is at least three-fold higher than the NOAEL for general toxicity effects. This suggests that 2-VP does not selectively target the reproductive organs. Regulatory action based on the NOAEL for systemic toxicity will insure protection of specific reproductive effects.
Short description of key information:
Review of the toxicity of reproductive organs in rats after subchronic exposure to 2VP indicates only generalized toxicity at doses higher than those showing systemic toxicity. This indicates that 2-VP does not selectively target the reproductive organs. Regulatory action to protect against systemic toxicity will insure protection against specific reproductive effects
Effects on developmental toxicity
Additional information
Risk assessment for teratogenicity is performed qualitatively, based on a categorical structure-activity relationship (SAR). Using a validated SAR model of teratogenicity in humans based on 323 chemical substances, 2VP was predicted to be "inactive" or "not teratogenic".
Justification for classification or non-classification
Existing in vivo studies of rats exposed to 2-vinylpyridine have been reviewed to ascertain the potential for reproductive toxicity. Concerning fertility, minor effects in the reproductive organs were observed at doses higher than those associated with general toxicity. Concerning teratogenicity, a structure-activity model predicts that 2 -VP is inactive (non-teratogenic).
Using a weight of evidence approach, 2-VP is not considered a reproductive toxicant. Further testing is not appropriate, as this substance is corrosive at the site of contact. Protection of workers against general toxicity will protect against any potential effects on the reproductive tract.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.