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Diss Factsheets
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EC number: 202-879-8 | CAS number: 100-69-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
2 -Vinylpyridine (2VP) has undergone biodegradation testing in several different protocols (301E Ready Biodegradation screening test, 301C Ready Biodegradation by the MITI protocol, and an inherent biodegradation test protocol where evaporation is prevented (CONCAWE inherent biodegradation protocol). All test results indicate poor biodegradation. These results are in contrast with a model prediction (BIOWIN, U. S. EPA) based on chemical structure. The biodegradation assays and the model predictions are each discussed below.
The BIOWIN model contains seven predictive modules. Although the overall prediction for the ready biodegradability of 2VP was negative, the results from three of the modules were indicative of rapid biodegradability (BIOWIN 1, BIOWIN 3 and BIOWIN 7); the results of a seventh module (BIOWIN 4) indicated that the primary degradation timeframe is days to weeks. The primary structural feature shaping the prediction is the pyridine ring, a substance which has been demonstrated to be biodegradable.
The result of the CONCAWE inherent biodegradation test ("0" biodegradation) of 56 days duration suggests that 2VP has reacted with other substances or itself to autopolymerise. Reactivity is the hallmark of 2VP’s functionality as a commercial chemical; in order to maximize product quality, it is recommended to transport and distribute the substance in refrigerated stainless steel containers. Reactivity is also suggested by its corrosivity to biological tissues. Further testing in biodegradation test protocols is not indicated, as all test media will provide chemical substances which will react with 2VP or result in dilution of the polymerisation inhibitor.
As 2VP is not readily biodegradable, it is classified as “Persistent” in the environment. However, classification of the material as "very Persistent" is premature until the degree of complexation, polymerization and /or reactivity which may be occurring is elucidated. The demonstrated biodegradability of the pyridine ring (the largest structural fragment in 2VP) and the predicted timeframe for primary biodegradability of 2VP (i.e., days to weeks, as determined by the BIOWIN 4 module) demonstrate that primary degradation of 2VP likely occurs in the environment and that the substance does not meet the criteria for classification as “very Persistent”.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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