Registration Dossier
Registration Dossier
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EC number: 202-879-8 | CAS number: 100-69-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- similar to a guideline study, undertaken in a corporate laboratory at a time when reporting of minimal data was routine. Only basic data is provided in this report. Due to the corrosive nature of the substance, consideration of repeating this study is inappropriate and not in the spirit of minimizing animal testing, according to the REACH legislation.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were administered (by gavage) various doses of test material. The number of rats surviving was observed, and the LD50 was calculated.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-vinylpyridine
- EC Number:
- 202-879-8
- EC Name:
- 2-vinylpyridine
- Cas Number:
- 100-69-6
- Molecular formula:
- C7H7N
- IUPAC Name:
- 2-ethenylpyridine
- Details on test material:
- test material = 98.95% pure
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Statistics:
- not stated
Results and discussion
- Preliminary study:
- Oral LD50 in male and female rats was 336 mg/kg.
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 336 mg/kg bw
- 95% CL:
- > 240 - < 472
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 336 mg/kg bw
- 95% CL:
- > 240 - < 472
- Clinical signs:
- other: Clinical signs of toxicity included prostration, weakness, tremors, vasodilation, excessive salivation and anorexia.
Any other information on results incl. tables
Oral LD50 in male and female rats was 336 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Oral LD50 (rat) = 336 mg/kg (confidence limits = 240-472 mg/kg). This corresponds to GHS Acute Toxicity Category IV.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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