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EC number: 213-590-1
CAS number: 991-84-4
The acute skin irritation / corrosion property of the test substance was
determined in a study similar to OECD guideline 404 after single dermal
administration to rabbits. 0.5 g of the test substance was prepared as
50 % suspension in polyethylene glycol and saline (70 : 30 parts) on a
gauze patch (2.5 x 2.5 cm) and applied occlusively to the intact and
abraded skin of 3 New Zeeland White rabbits of each sex for 24 hours.
The skin reaction was appraised upon removal and during an observation
period of 7 days on the basis of the Draize scoring system. Mean 24 - 48
- 72 hour scores were 0 for erythema and edema for the intact skin. In
conclusion, the test substance revealed no skin irritating potential,
even under more stringent conditions as required in the guideline.
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