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EC number: 213-590-1
CAS number: 991-84-4
Table 1: Body weight in male and female animals after day 0, 7 and 14
Body weight [g]
Males (dose = 1600 mg/kg bw)
Females (dose = 1600 mg/kg bw)
The acute dermal toxicity of the test substance was assessed in a
toxicity study following OECD guideline 402 and in compliance with GLP.
The test article was administered to five rats of each sex by dermal
application at 1600 mg/kg body weight for 24 hours. Higher doses were
technically not possible. Animals were subjected to daily observations
and weekly determination of body weight. Macroscopic examination was
performed after terminal sacrifice. No mortality occurred. Piloerection
was seen, being a common symptom in acute dermal tests. The animals
recovered within 2 days. At autopsy, no deviations from normal
morphology were found. The dermal LD50 value of the test substance in
rats was established to exceed 1600 mg/kg body weight.
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