Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-590-1
CAS number: 991-84-4
In an acute eye irritation study similar to OECD guideline 405, 0.1 g of
the test substance was administered to 3 male and 3 female New Zeeland
White rabbits. The test substance was placed into the conjunctival sac
of the left eye of each animal; the right eye remained untreated and
served as control. In 3 of the 6 rabbits approximately 30 seconds after
treatment the treated eye was flushed with 10 ml of physiological
saline. The eye irritation was evaluated according to Draize on day 1,
2, 3, 4, and 7. The cornea and iris scores were grade 0 in the mean over
24, 48 and 72 hours in all 6 animals (both with and without washing).
The conjunctiva score was 0.4 for the animals whose eyes were washed and
0.3 for the animals whose eyes were not washed, respectively. The
redness was reversible within 72 hours. The chemosis score was grade 0.1
in the mean over 24, 48 and 72 hours in all 6 animals (both with and
without washing) and the eye irritating effect was fully reversible
within 48 hours. Concluding, the test substance revealed no eye
irritating properties under the test conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again