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EC number: 213-590-1
CAS number: 991-84-4
The test substance is a white powder with a molecular weight of 558.96
g/mol. The logPow value is 13 and the solubility in water is 20 µg/l
(20°C, pH 6). The vapour pressure was estimated to 1.333E-10 Pa.
According to the physico-chemical properties (molecular weight, logPow)
the test substance is expected not to be absorbed through the
gastrointestinal tract (ECHA R7c). This is supported by an absorption
study conducted according to the Levine technique (Geigy Chemicals
Corporation, 1965 and 1966), which was performed to analyse the
absorption potential of the test substance along the gastro intestinal
tract.14C labelled test material was
injected into the gut lumen of rats for 3 hours. The test compound was
detected to be poorly absorbed. Further support is given by an acute
oral toxicity study. TIF: RAIf (SPF) rats were administered a dose of
3000 mg/kg body weight per gavage (Ciba-Geigy, 1980). No mortalities and
no treatment related clinical signs occurred and the LD50 oral was set
to be > 3000 mg/kg body weight. Additionally, a subacute study in Tif:
RAIf (SPF) rats (Ciba-Geigy, 1983) supports the assumption, that the
test substance is not absorbed through the gastro intestinal tract. The
test material was administered via the diet in doses of 97 – 1010 mg/kg
bw for male rats and 91 - 897 mg/kg bw for female rats for 28 days. No
test material related effects were observed. Furthermore, in two
independent subchronic studies conducted in Sprague-Dawley rats (Geigy
Pharmaceuticals, 1974) and beagle dogs (Geigy Pharmaceuticals, 1974) the
test substance was administered in the diet in doses up to 1297.3 mg/kg
body weight in rats and 818 mg/kg body weight in dogs, respectively. In
both studies no test material related adverse effects were observed.
The dermal uptake of the test substance is unlikely due to its
physico-chemical parameters. The test substance did not exhibit any
acute dermal toxicity (Ciba-Geigy, 1992), skin irritative / corrosive
(Ciba-Geigy, 1981), eye irritative (Ciba-Geigy Ltd, 1981) or skin
sensitisation properties (Ciba-Geigy, 1982), respectively.
The acute inhalative toxicity study (Ciba-Geigy, 1973) did not reveal
signs for bioavailability via the respiratory pathway. Tif. RAI rats
were exposed using a nose-only system to a technically maximal
achievable analytical substance concentration of 1 mg/l for 4 hours and
did not show any clinical sign of toxic effects of the test substance.
As the test substance is a solid and its vapour pressure is estimated to
be 1.333E-10 Pa, absorption via inhalation is unlikely. No information
is available about dustiness of the test substance. However, in light of
its low water solubility, there is a likelihood of deposition in the
lung if exposure to particulate aerosols should occur.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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