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Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

According to the study report the degradation of the read across substance quinine base anhydrous was 86.3% within 28 days (after acidification). The read across substance quinine reached the criterion for ready biodegradability. Therefore, we assumed that quinine dihydrochloride is also readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable

Additional information

The read across substance quinine base anhydrous was tested in a CO2 Evolution Test according to the OECD Guideline 301 B for 28 days (and 29 days after acidification) to determine whether the test substance is readily biodegradable. After a lag phase of 10 days, the degradation extent of the test item reached 86.3 % by the end of the test (mean of three replicates). The reference compound sodium benzoate reached the pass levels for ready biodegradability within 3 days. The degradation of the toxicity control after 14 days was 86.6%. Thus, quinine had no inhibitory effects to the inoculum according to the criterion of the guideline. The read across substance quinine base anhydrous reached the criteria for ready biodegradability (60% ThCO2) within the 10-day time window. Therefore, quinine base anhydrous can be considered to be readily biodegradable. Thus, we assumed that quinine dihydrochloride is also readily biodegradable.