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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study is not done according to OECD guideline, but it is a well documented study

Data source

Reference
Reference Type:
publication
Title:
The action of the cinchona and certain other alkaloids in bird malaria II.
Author:
Buttle, G. A. H., Henry, T. A.and Trevan, J. W.
Year:
1934
Bibliographic source:
Biochem J. 28(2):426-441

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The toxicity of the substance was examined by intravenous injection into mice. The lethal doses were recorded and the LD50 estimated.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): Quinidine dihydrochloride

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other:
Effect level:
ca. 52.5 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 10% of the animals died
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 70 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% of the animals died
Sex:
not specified
Dose descriptor:
other:
Effect level:
ca. 75 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 60% of the animals died
Sex:
not specified
Dose descriptor:
LD100
Effect level:
ca. 95 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 5 of 5 animals died

Any other information on results incl. tables

 Drug Dose in mg of base per 20 g mouse  Mortality Estimate of average lethal dose of base 20 g mouse (mg)
 Quinine dihydrochloride  1.05  1/10  1.4
   1.5 6/10   
   1.9  5/5  
   2.25 10/10  

Applicant's summary and conclusion

Conclusions:
The LD50 of quinine dihydrochloride tested on mouse via intravenous injection is 70 mg/kg bw.
Executive summary:

In the study published by Buttle, 1934 the acute toxicity of quinine dihydrochloride was tested on mouse via an intravenous injection. The experimental study shows that, the LD50 of quinine dihydrochloride is 70 mg/kg bw.