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EC number: 941-793-1
CAS number: -
Viability / Mortality
No deaths occurred during the study period.
No symptoms of local toxicity at the ears of the animals and no systemic
findings were observed during the study period.
The body weight of the animals, recorded prior to the first application
and prior to treatment with 3HTdR, was within the range commonly
recorded for animals of this strain and age.
Lymph Node Weights and Cell Counts
The measured lymph node weights and –cell counts of all animals treated
were recorded after sacrifice. A statistically significant or
biologically relevant increase in lymph node weights was not observed in
any of the test item treated groups in comparison to the vehicle control
group. For BALB/c mice, a cutoff-value for the lymph node cell count
index of 1.55 was reported for a positive response. The indices
determined for the lymph node cell count did not exceed this threshold.
The measured ear weights of all animals treated were recorded after
sacrifice. A statistically significant or biologically relevant increase
in ear weights was not observed in any treated group in comparison to
the vehicle control group.
For BALB/c mice, a threshold for the ear weight index of 1.1 was
reported for a positive response. The indices determined for the lymph
node cell count did not exceed this threshold. Furthermore, according to
OECD guideline 429, an increase in ear weight exceeding the threshold
value of 25% was considered to be indicative for excessive local skin
irritation. This threshold was not exceeded in any test item treated
In order to study a possible skin sensitisation potential of
2-Propyn-1-ol, compd. with methyloxirane, 3 groups each of 5 female mice
were treated once daily with the test item at concentrations of 25, 50%
and 100% in dimethylformamide by topical application to the dorsum of
each ear for three consecutive days according to OECD 429 in compliance
A control group of 5 mice was treated with the vehicle
(dimethylformamide) only. All treated animals survived the scheduled
study period and no signs of systemic toxicity or local skin irritation
The Stimulation Indices (S.I.) of 0.60, 1.14, and 0.71 were
determined with the test item at concentrations of 25, 50% (w/w) and
100% in dimethylformamide, respectively. An outlier was identified in
the mid dose group but it did not change the overall test result and was
not excluded from calculation.A statistically significant increase in
DPM value, lymph node weight and also in lymph node cell count was not
observed in any of the tested dose groups in comparison to the vehicle
control group. Furthermore, the cutoff-value for a positive response
regarding the lymph node cell count index of 1.55 reported for BALB/c
mice was not exceeded in any dose group.
An EC3 value could not be calculated, since none of the tested
concentrations induced a S.I. greater than the threshold value of 3.
The test item 2-Propyn-1-ol, compd. with methyloxirane was not
a skin sensitiser under the test conditions of this study (BASF,
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