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EC number: 941-793-1 | CAS number: 32199-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study; however, basic parameters are documented and study was conduced similar to OECD 403.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Principles of method if other than guideline:
- This test was performed in principle as described in OECD Guideline 403.
Deviations: 3 rats per sex were exposed, two exposure times (8hours and 3 hours) instead of 4h, clinical signs was perfomred over 7 days - GLP compliance:
- no
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Reference substance 002
- EC Number:
- 607-802-5
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Propargylglykol, Ethylenglykol-monopropargyl-ether
- Molecualr weight: 100.12 g/mol
- densitiy: 1.02-1.04 g/cm3
- Puritiy: 98%
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: average 168 g (8hours-study) and 185g (3hours-study)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20
- Air changes (per hr): 200Ltr
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Vapor was generated by bubbling 200l/h air through a substance column of about 5cm above a fritted glass disc.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Remarks on duration:
- another timepoint was 3 hours of exposure
- Concentrations:
- 1,33 mg/l
- No. of animals per sex per dose:
- 3
- Control animals:
- yes
- Details on study design:
- Several groups of 3 rats per sex were exposed sequentially to the vapors,
generated by bubbling 200 1/h air through a substance column of about 5 cm above a
fritted glass disc in a glass cylinder for 3 and 8 hours.
Group-wise documentation of clinical signs was performed over a 7- day study period. Body weight of groups was determined before the start of the study and at the end of the Observation period in surviving animals.
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, gross pathology
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 1.33 mg/L air
- Based on:
- act. ingr.
- Exp. duration:
- 8 h
- Remarks on result:
- other: Attention, increased exposure time (8h) instead of todays used 4h. See "Remarks on results"
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 1.34 mg/L air
- Based on:
- act. ingr.
- Exp. duration:
- 3 h
- Mortality:
- No mortality occured in this study after 3hours of exposure.
Exposure of 8hours conducted to one dead animal after 24h, one dead animal after 48h and one dead animal after 72h, so that half of the animals were dead after 72hours. - Clinical signs:
- other: 3h-Exposure: no effects 8h-Exposure: -strong mucosa irritation - nose, discharge, bloody - dyspnea
- Gross pathology:
- Heart: acute dilatation and accumulation of blood
Liver: yellow coloured
stomach: dilatation
lung: acute flatulence - Other findings:
- 8h exposure: 3 of 6 animals were dead within 3 days after exposure. Survivors showed no effects after 3 days and were killed at the end of this study after 7 days.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Remarks:
- Migrated information GHS Criteria used for interpretation of results: EU
- Executive summary:
This test was performed in principle as described in OECD Guideline 403 without GLP compliance.
3 rats per sex were exposed sequentially to the vapor, generated by bubbling 200 1/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 3 hours and 8 hours. Documentation of clinical signs and mortality was performed over 7 days.
No mortality occured in this study after 3hours-exposure. Exposure of 8hours conducted to one dead animal after 24h, one dead animal after 48h and one dead animal after 72h, so that half of the animals were dead after 72hours.
The classification criteria for acute inhalation toxicity relate to a 4h experimental exposure period. After adjustment to a 4h-equivalent by Haber´s law (c^n*t=constant), an LC50 of 1,67 mg/l/4h could be calculated and therefore the test item should be classified as inhalation toxic category 2. (BASF, 1975)
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