Registration Dossier
Registration Dossier
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EC number: 212-572-0 | CAS number: 827-52-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Under the conditions of the present key study the 96h LC50 for O. lapides exposed to cyclohexylbenzene is 1.2 mg/l.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.2 mg/L
Additional information
There are two acute fish toxicity studies available, both following recent guidelines and performed according to GLP. The first study (Aufderheide, 2001) reported no acute toxicty to P. promelas after exposure to cyclohexylbenzene. The NOEC was determined to be 10 mg/L, being the highest concentration tested. Consequently, it can be concluded that no acute toxicity was observed in this test up to the water solubility level of cyclohexylbenzene.
The second study is perfomed by the ministry of health and environment of Japan. In this study another fish species was used (O. latipes) and a LC50 of 1.2 mg/L was determined. Please note that acetone was used as a solvent in this study. The study is written in Japanese but the results and main information on the methodology are given in table format.
Based on the precautionary principle, the study by the Japanese ministry of environment is considered to be the key study. An LC50 of 1.2 mg/L is therefore taken into account for the risk assessment.
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