Registration Dossier
Registration Dossier
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EC number: 206-743-9 | CAS number: 372-09-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No data are available.
Additional information
No data are available.
Effects on developmental toxicity
Description of key information
In an invalid study, Cyanoacetic acid did not induce cleft plates in fetuses of rats treated with the test substance on day 15 of gestation.
Additional information
In a developmental toxicity study (Wilk et al 1972) Cyanoacetic acid (purity not given) was administered to at least 8 female Sprague-Dawley rats/dose by gavage at dose levels of 0 or ca. 2040 mg/kg bw/day on day 15 of gestation.
No data are given on maternal toxicity. No cleft palates were observed the fetuses. No other endpoints were examined. NOAELs were not established.
The developmental toxicity study in the rat is classified unacceptable because of significant methodological deficiencies and does not satisfy the guideline requirement for a developmental toxicity study (OPPTS 870.3700; OECD 414) in rats (only one dose level tests, only single dosing, low number of animals, limited examinations).
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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