Registration Dossier
Registration Dossier
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EC number: 206-743-9 | CAS number: 372-09-8
Endpoint summary
Administrative data
Description of key information
ORAL
No adverse effects were observed in an invalid 7-week drinking water study with rats. A NOAEL was not established.
DERMAL and INHALATION
No data are available.
Key value for chemical safety assessment
Additional information
ORAL
In a subchronic toxicity study (Lalich 1958) Cyanoacetic acid was administered to 3 and 4 female Sprague-Dawley rats in water at dose levels of 0 and 2000 ppm (0 and ca. 330 mg/kg bw/day), respectively, for 7 weeks.
There were no compound related effects in mortality, body weight gain, and gross pathology. No changes of mesodermal tissue and no skeletal deformities were observed. No other endpoints were examined. A NOAEL was not established.
This subchronic toxicity study in the rat is unacceptable because of significant methodological deficiencies and does not satisfy the guideline requirement for a subchronic oral study (OPPTS 870.3100; OECD 408) in rats (only one dose level tested, low number of animals, limited examinations).
DERMAL and INHALATION
No data are available.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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