Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-743-9 | CAS number: 372-09-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a dermal sensitization study (Degussa 1984; and cited in SIAR 2006) with Cyanoacetic acid (purity 99.3%), guinea pigs were tested using the method of Buehler. the method followed was that described in the EPA Health Effects Testing Guidelines, Subpart E- Specific Organ/Tissue Toxicity . In this study, Cyanoacetic acid did not produce evidence of skin sensitisation (delay contact hypertensitivity) in any test animals.
Migrated from Short description of key information:
Cyanoacetic acid is not a dermal sensitizer in guinea pigs (Buehler test).
Respiratory sensitisation
Endpoint conclusion
- Additional information:
In a dermal sensitization study (Degussa 1984; and cited in SIAR 2006) with Cyanoacetic acid (purity 99.3%), guinea pigs were tested using the method of Buehler. the method followed was that described in the EPA Health Effects Testing Guidelines, Subpart E- Specific Organ/Tissue Toxicity . In this study, Cyanoacetic acid did not produce evidence of skin sensitisation (delay contact hypertensitivity) in any test animals.
Justification for classification or non-classification
Based on the data available, there is no need to classify Cyanoacetic acid for skin sensitisation according to the Directive 67/548/EC or GHS criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
