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EC number: 232-476-2
CAS number: 8050-15-5
Disintegrations per minute/node:
No mortality or signs of toxicity were noted
during the study.
Body weights and body weight changes in test
substance-treated animals were comparable to controls.
In a skin sensitization study using the
Local Lymph Node Assay, three groups of 4 (CBA/CaCruBR) female mice were
administered daily applications of 50 µL (25 µL per ear) Glycerol Ester
of Tall Oil at test concentrations of 0.5, 5, and 50% (w/v) in a 4:1
acetone:olive oil vehicle for 3 consecutive days. A control group of 4
mice received the vehicle only. Five days after the
first application, the animals were injected via the tail vein with 250
µL of phosphate buffered saline containing ^3H-methyl thymidine and
euthanized 5 hours later. The auricular lymph nodes were collected and a
single cell suspension was prepared for each dose group. The
^3HTdR incorporation by the cells was determined and a Stimulation Index
(SI) calculated for each dose concentration of the test material. A
Stimulation Index of less than 3.0 was recorded for all dose
concentrations. Under the conditions of the study, Glycerol Ester of
Tall Oil (resin acids and rosin acids, tall-oil, esters with glycerol)
is not a moderate or strong skin sensitizer in mice.
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