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EC number: 232-476-2
CAS number: 8050-15-5
In an acute oral toxicity study, a group of
five male rats was administered a single dose of Resin acids and Rosin
acids, hydrogenated, Me esters by gavage at a dose level of 2000 mg/kg
bw. Serving as controls, an additional group of five male rats was
administered distilled water at 2.0 mL/kg bw. All rats were observed for
mortality and adverse clinical signs for a period of 14 days. No
mortality was noted in either treated or control animals. Immediately
following dosing of the test substance, excitation and the appearance of
piloerection were observed. These observations disappeared over the
following hours. No abnormal clinical signs were recorded for control
animals. Daily examinations for 14 days following treatment showed no
changes in the state or behavior of the animals. All treated and control
animals gained weight over the course of the study. At necropsy, no
gross lesions were observed. The oral LD50 in male rats is considered to
be greater than 2000 mg/kg bw. Based on the results of this study, Resin
acids and Rosin acids, hydrogenated, Me esters is considered to be a low
toxicity hazard upon ingestion.
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