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EC number: 202-338-6
CAS number: 94-49-5
Evaluation of the toxicokinetic properties
(i.e. absorption, metabolism, distribution and elimination) of the
substance is a requirement. The information can contribute in the
understanding of the toxicological profile and assist in testing
strategy and study design.
The purpose of this study was to assess the
toxicokinetic properties of ethylene dibenzoate (EGDB, CAS 94-49-5).
The toxicokinetic properties of EGDB are
evaluated using free and commercially available computerized models as
well as available study information on the substance itself.
EGDB is a mono-constituent of at least 99.4%
purity and has a molecular weight of 270.28 g/mole. It is a solid at
room temperature. Based on information from property profiling as well
on information on studies on EGDB, the following statements can be made:
- Oral absorption: the bioavailability of
EGDB, following dissociation of the salt in the Gastro- Intestinal
tract, is considered to be high via oral route. A provisional absorption
rate of 100% is set for the oral route.
- Dermal absorption: Dermal absorption of
EGDB is expected to be high. A provisional absorption rate of 100% is
set for the dermal route.
- Respiratory absorption: Likelihood of
exposure via inhalation is low considering the very low vapor pressure.
Exposures are only possibly to aerosols that will deposit mainly in
upper airways, and will be subsequently swallowed after mucociliary
transportation to pharynx. No principal difference is therefore expected
in absorption between exposures via inhalation route and oral route as
high in respiratory tract. Absorption via inhalation therefore also set
- It is predicted that EGDB is rapidly
absorbed, distributed over the whole body and excreted again
- EGDB has no bioaccumulation potential
(LogPow 3.75 (just above 3) and readily biodegradable).
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