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EC number: 202-338-6
CAS number: 94-49-5
Table 1 Mean
Number of Micronucleated Polychromatic Erythrocytes and Ratio of
(mg/kg body weight)
Number of micronucleated polychromatic erythrocytes
Ratio polychromatic/ normochromatic erythrocytes
(mean ± S.D.)(a,b)
(mean ± S.D.)(a,c)
Vehicle control = PEG400
CP = Cyclophosphamide.
(a)Five animals per treatment group. ; (b)At
least 4000 polychromatic erythrocytes were evaluated with a maximum
deviation of 5%.; (c)The ratio was determined from at least
the first 1000 erythrocytes counted.; (d)Significantly
different from corresponding control group (Students t test, Welch t
test, P < 0.001).
Table 2 Historical data for the vehicle controls (males)
Mean number of micronucleated polychromatic erythrocytes per 2000 cells
Upper control limit
(95% control limits)
Lower control limit
SD = Standard deviation; n = Number of observations
Distribution historical negative control data from experiments
performed between January 2012 and October 2017.
Table 3 Historical data for the positive controls (males)
In a bone marrow micronucleus test with male mice, performed according
to OECD guideline 474 and GLP principles, it is concluded that Ethylene
glycol dibenzoate is not clastogenic or aneugenic up to and including a
dose level of 2000 mg/kg bw.
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