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EC number: 601-601-6
CAS number: 119345-04-9
Groups of male and female rats were maintained for a
period of two years on diets containing 1.0, 0.3, 0.1, or 0.03% Benax
2A1 (DOWFAX 2A1) without evidence of adverse effect as judged by general
appearance and behavior, mortality, incidence of tumorous growths, food
consumption, hematological studies, serum urea nitrogen and alkaline
phosphatase determinations, bone marrow examination, final average body
and organ weights, and gross and microscopic examination of the tissues.
On a body weight basis, the test substance was consumed in the amounts
of 500, 150, 50, or 15 mg./kg/day by the rats on these levels.
The only evidence of any adverse effect whatsoever was
seen in the rats which received 1.0 percent (500 mg./kg./day) Benax 2A1
in their diets. Growth was depressed in the group of female rats on this
level, with a statistically significant decrease in the final average
body weight at the end of two years. The group of male rats showed a
slighter, statistically insignificant growth retardation.
In the available studies with DOWFAX 2A1, there is no evidence of tumour
formation up to the highest (1% in the diet) doses tested in rats and
dogs. DOWFAX family of surfactants is also not genotoxic. Therefore, no
CLP classification for carcinogenicity is proposed for this substance.
DOWFAX 2A1 was administered in diet up to 1% dose level to rats and dogs
over 2 year period. No significant differences in lesion incidence were
observed in the tissues of dogs and rats given diets containing up to
the highest DOWFAX 2A1 dose compared with the respective controls. NOAEL
for carcinogenicity is > 1% in the diet (>319 mg/kg bw/day for dogs and
>500 mg/kg bw/day for rats).
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