Benzene, 1,1'-oxybis-, tetrapropylene derivs., sulfonated, sodium salts

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was not conducted according to guideline/s and GLP, but the report contains sufficient data for interpretation of study results.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Three female Fischer 344 rats received 2000 mg/kg of the neat test material by single-dose oral gavage. Observations and body weights were recorded over a 2-week period following dosing.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzene, 1,1'-oxybis-, tetrapropylene derivs., sulfonated, sodium salts

EC Number:

601-601-6

Cas Number:

119345-04-9

Molecular formula:

C24H32O7S2Na2

IUPAC Name:

Benzene, 1,1'-oxybis-, tetrapropylene derivs., sulfonated, sodium salts

Details on test material:

Test material: Dowfax 2A1
Source: Specialty Chemicals, The Dow Chemical Company
Properties: Amber liquid
pH= 7.0

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

female

Details on test animals or test system and environmental conditions:

No data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

2000 mg/kg of the neat test material by single-dose oral gavage

Doses:

2000 mg/kg

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

Three female Fischer 344 rats received 2000 mg/kg of the neat test material by single-dose oral gavage. Observations and body weights were recorded over a 2-week period following dosing.

Statistics:

None

Results and discussion

Preliminary study:

None

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

No mortality

Clinical signs:

other: Clinical signs indicative of systemic toxicity in the 2000 mg/ kg dose level consisted of fecal and urine soiling, salivation, chromorhinorrhea, decreased activity, and thin appearance. The clinical signs were first observed two hours post dose and persis

Gross pathology:

None

Other findings:

No data

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Remarks:

Criteria used for interpretation of results: other: EU GHS

Conclusions:

The estimated acute oral LD50 for female Fischer 344 rats was greater than 2000 mg/kg.

Executive summary:

A sample of Dowfax 2A1 was submitted by Specialty Chemicals, The Dow Chemical Company, Midland, MI for evaluation of acute oral and dermal toxicity and skin and eye irritation. In the acute oral toxicity test, three female Fischer 344 rats received 2000 mg/kg of the neat test material by single-dose oral gavage. Clinical signs indicative of systemic toxicity in the 2000 mg/kg dose level consisted of fecal and urine soiling, salivation, chromorhinorrhea, decreased activity, and thin appearance. The clinical signs were first observed two hours post dose and persisted through test day four. While one of these rats initially lost weight, all animals gained weight over the two-week observation period. The estimated acute oral LD50 for female Fischer 344 rats was greater than 2000 mg/kg.