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EC number: 944-461-4
CAS number: -
One study is available testing the bioconcentration potential of
Reaction mass of
in fish. Since the study shows some limitations a QSAR was additionally
conducted in order to gain a better impression of the bioaccumulative
potential of the substance.
In the study conducted according OECD 305, Cyprinus carpio (carp) was
exposed for 63 d to two concentration levels of 0.01 mg/L and 0.001 mg/L
(nominal). The BCF was found to lie between <9 and 45 at the high
concentration level of the test item and between <76 and 94 at the low
concentration level. However, the study shows some limitations. A
solvent (tetrahydrofuran) was used as a vehicle in a higher
concentration than recommended by the guideline. The BCF steady state
could not be calculated and the bioconcentration factors were not
corrected for lipid content.
Therefore, an additional QSAR calculation (BCFBAF v3.01, EPISUITE v
4.11) was performed and resulted to a BC factor of 60.74 L/kg for the
upper trophic including a biotransformation rate of 0.0001852 /day (for
10 g fish). This result further indicates a low bioaccumulative
potential of the substance. The substance does not meet completely the
applicability domain of the model and results have to be carefully
Physicochemical and toxicokinetic data give additional hints about the
bioaccumulative fate of Reaction mass of
The substance has a high molecular weight of 971.68 g/mol and a high log
Kow of > 10 (OECD 117). According to guideline (EC) No 1907/2006 these
parameters indicate low bioaccumulation potential of the substance due
to limited bioavailability. The toxicokinetic assessment also states a
very low potential of absorption by the oral or the dermal route. No
deaths or systemic toxicity were observed in acute oral or dermal
toxicity studies. The high molecular weight indicates low potential of
the substance to be absorbed through intestinal wall and enter the
systemic circulation. Additionally, the substance is very insoluble in
liquid solutions so it's not easily to be dissolved in gastrointestinal
fluids (for more details see section 7.1). Furthermore, no toxic effects
were observed in any of the aquatic toxicity studies.
Based on this wide range of evidence a low bioaccumulation potential of
the substance in biota is expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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